ParkinsonCanadaV1, Main, Exploration, bibRecord, 001540

Defective dentate nucleus GABA receptors in essential tremor

Identifieur interne : 001540 ( Main/Exploration ); précédent : 001539; suivant : 001541

Defective dentate nucleus GABA receptors in essential tremor

Auteurs : Sarah Paris-Robidas [Canada] ; Elodie Brochu [Canada] ; Marion Sintes [Canada] ; Vincent Emond [Canada] ; Mélanie Bousquet [Canada] ; Milène Vandal [Canada] ; Mireille Pilote [Canada] ; Cyntia Tremblay [Canada] ; Therese Di Paolo [Canada] ; Ali H. Rajput [Canada] ; Alex Rajput [Canada] ; Frederic Calon [Canada]

Source :

Brain [ 0006-8950 ] ; 2012.

RBID : Pascal:12-0113652

Descripteurs français

Pascal (Inist)
- Tremblement, Pathologie du système nerveux, Noyau dentelé, Récepteur gabaergique, Cervelet.

English descriptors

KwdEn :
- Cerebellum, Dentate nucleus, Gabaergic receptor, Nervous system diseases, Tremor.

Abstract

The development of new treatments for essential tremor, the most frequent movement disorder, is limited by a poor unde standing of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA_A (35% reduction) and GABA_B (22-31 % reduction) receptors in the dentate nucleus of the cerebellum from individua with essential tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding auti radiography. Concentrations of GABA_B receptors in the dentate nucleus were inversely correlated with the duration of essenti tremor symptoms (r² = 0.44, P < 0.05), suggesting that the loss of GABA_B receptors follows the progression of the disease. situ hybridization experiments also revealed a diminution of GABA_B(1a+b) receptor messenger RNA in essential tremor (↓27%). In contrast, no significant changes of GABA_A and GABA_B receptors (protein and messenger RNA), GluN2B receptors, cytochrorr oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagatir along the cerebello-thalamo-cortical pathways to generate tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in essential tremor.

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000221
to stream PascalFrancis, to step Curation: 000A31
to stream PascalFrancis, to step Checkpoint: 000182
to stream Main, to step Merge: 001596
to stream Main, to step Curation: 001540

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Defective dentate nucleus GABA receptors in essential tremor</title>
<author><name sortKey="Paris Robidas, Sarah" sort="Paris Robidas, Sarah" uniqKey="Paris Robidas S" first="Sarah" last="Paris-Robidas">Sarah Paris-Robidas</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brochu, Elodie" sort="Brochu, Elodie" uniqKey="Brochu E" first="Elodie" last="Brochu">Elodie Brochu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sintes, Marion" sort="Sintes, Marion" uniqKey="Sintes M" first="Marion" last="Sintes">Marion Sintes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emond, Vincent" sort="Emond, Vincent" uniqKey="Emond V" first="Vincent" last="Emond">Vincent Emond</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vandal, Milene" sort="Vandal, Milene" uniqKey="Vandal M" first="Milène" last="Vandal">Milène Vandal</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pilote, Mireille" sort="Pilote, Mireille" uniqKey="Pilote M" first="Mireille" last="Pilote">Mireille Pilote</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tremblay, Cyntia" sort="Tremblay, Cyntia" uniqKey="Tremblay C" first="Cyntia" last="Tremblay">Cyntia Tremblay</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Therese" last="Di Paolo">Therese Di Paolo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, Royal University Hospital, University of Saskatchewan</s1>
<s2>Saskatoon, SK S7N 0W8</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, SK S7N 0W8</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, Royal University Hospital, University of Saskatchewan</s1>
<s2>Saskatoon, SK S7N 0W8</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, SK S7N 0W8</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frederic" last="Calon">Frederic Calon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0113652</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0113652 INIST</idno>
<idno type="RBID">Pascal:12-0113652</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000221</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000A31</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000182</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000182</idno>
<idno type="wicri:doubleKey">0006-8950:2012:Paris Robidas S:defective:dentate:nucleus</idno>
<idno type="wicri:Area/Main/Merge">001596</idno>
<idno type="wicri:Area/Main/Curation">001540</idno>
<idno type="wicri:Area/Main/Exploration">001540</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Defective dentate nucleus GABA receptors in essential tremor</title>
<author><name sortKey="Paris Robidas, Sarah" sort="Paris Robidas, Sarah" uniqKey="Paris Robidas S" first="Sarah" last="Paris-Robidas">Sarah Paris-Robidas</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brochu, Elodie" sort="Brochu, Elodie" uniqKey="Brochu E" first="Elodie" last="Brochu">Elodie Brochu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sintes, Marion" sort="Sintes, Marion" uniqKey="Sintes M" first="Marion" last="Sintes">Marion Sintes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Emond, Vincent" sort="Emond, Vincent" uniqKey="Emond V" first="Vincent" last="Emond">Vincent Emond</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vandal, Milene" sort="Vandal, Milene" uniqKey="Vandal M" first="Milène" last="Vandal">Milène Vandal</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pilote, Mireille" sort="Pilote, Mireille" uniqKey="Pilote M" first="Mireille" last="Pilote">Mireille Pilote</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tremblay, Cyntia" sort="Tremblay, Cyntia" uniqKey="Tremblay C" first="Cyntia" last="Tremblay">Cyntia Tremblay</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Therese" last="Di Paolo">Therese Di Paolo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, Royal University Hospital, University of Saskatchewan</s1>
<s2>Saskatoon, SK S7N 0W8</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, SK S7N 0W8</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, Royal University Hospital, University of Saskatchewan</s1>
<s2>Saskatoon, SK S7N 0W8</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Saskatoon, SK S7N 0W8</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frederic" last="Calon">Frederic Calon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Pharmacy, Laval University</s1>
<s2>Quebec, QC G1V 0A6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Quebec, QC G1V 0A6</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</s1>
<s2>Quebec, QC G1V 4G2</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Centre Hospitalier de l'Université Laval (CHUL) Research Centre</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Brain</title>
<title level="j" type="abbreviated">Brain</title>
<idno type="ISSN">0006-8950</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Brain</title>
<title level="j" type="abbreviated">Brain</title>
<idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum</term>
<term>Dentate nucleus</term>
<term>Gabaergic receptor</term>
<term>Nervous system diseases</term>
<term>Tremor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term>
<term>Pathologie du   système nerveux</term>
<term>Noyau dentelé</term>
<term>Récepteur gabaergique</term>
<term>Cervelet</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The development of new treatments for essential tremor, the most frequent movement disorder, is limited by a poor unde standing of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA<sub>A</sub>
 (35% reduction) and GABA<sub>B</sub>
 (22-31 % reduction) receptors in the dentate nucleus of the cerebellum from individua with essential tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding auti radiography. Concentrations of GABA<sub>B</sub>
 receptors in the dentate nucleus were inversely correlated with the duration of essenti tremor symptoms (r<sup>2</sup>
 = 0.44, P < 0.05), suggesting that the loss of GABA<sub>B</sub>
 receptors follows the progression of the disease. situ hybridization experiments also revealed a diminution of GABA<sub>B(1a+b)</sub>
 receptor messenger RNA in essential tremor (↓27%). In contrast, no significant changes of GABA<sub>A</sub>
 and GABA<sub>B</sub>
 receptors (protein and messenger RNA), GluN2B receptors, cytochrorr oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagatir along the cerebello-thalamo-cortical pathways to generate tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in essential tremor.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Paris Robidas, Sarah" sort="Paris Robidas, Sarah" uniqKey="Paris Robidas S" first="Sarah" last="Paris-Robidas">Sarah Paris-Robidas</name>
</noRegion>
<name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name>
<name sortKey="Bousquet, Melanie" sort="Bousquet, Melanie" uniqKey="Bousquet M" first="Mélanie" last="Bousquet">Mélanie Bousquet</name>
<name sortKey="Brochu, Elodie" sort="Brochu, Elodie" uniqKey="Brochu E" first="Elodie" last="Brochu">Elodie Brochu</name>
<name sortKey="Brochu, Elodie" sort="Brochu, Elodie" uniqKey="Brochu E" first="Elodie" last="Brochu">Elodie Brochu</name>
<name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frederic" last="Calon">Frederic Calon</name>
<name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frederic" last="Calon">Frederic Calon</name>
<name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Therese" last="Di Paolo">Therese Di Paolo</name>
<name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Therese" last="Di Paolo">Therese Di Paolo</name>
<name sortKey="Emond, Vincent" sort="Emond, Vincent" uniqKey="Emond V" first="Vincent" last="Emond">Vincent Emond</name>
<name sortKey="Emond, Vincent" sort="Emond, Vincent" uniqKey="Emond V" first="Vincent" last="Emond">Vincent Emond</name>
<name sortKey="Paris Robidas, Sarah" sort="Paris Robidas, Sarah" uniqKey="Paris Robidas S" first="Sarah" last="Paris-Robidas">Sarah Paris-Robidas</name>
<name sortKey="Pilote, Mireille" sort="Pilote, Mireille" uniqKey="Pilote M" first="Mireille" last="Pilote">Mireille Pilote</name>
<name sortKey="Pilote, Mireille" sort="Pilote, Mireille" uniqKey="Pilote M" first="Mireille" last="Pilote">Mireille Pilote</name>
<name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name>
<name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
<name sortKey="Sintes, Marion" sort="Sintes, Marion" uniqKey="Sintes M" first="Marion" last="Sintes">Marion Sintes</name>
<name sortKey="Sintes, Marion" sort="Sintes, Marion" uniqKey="Sintes M" first="Marion" last="Sintes">Marion Sintes</name>
<name sortKey="Tremblay, Cyntia" sort="Tremblay, Cyntia" uniqKey="Tremblay C" first="Cyntia" last="Tremblay">Cyntia Tremblay</name>
<name sortKey="Tremblay, Cyntia" sort="Tremblay, Cyntia" uniqKey="Tremblay C" first="Cyntia" last="Tremblay">Cyntia Tremblay</name>
<name sortKey="Vandal, Milene" sort="Vandal, Milene" uniqKey="Vandal M" first="Milène" last="Vandal">Milène Vandal</name>
<name sortKey="Vandal, Milene" sort="Vandal, Milene" uniqKey="Vandal M" first="Milène" last="Vandal">Milène Vandal</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001540 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001540 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0113652
   |texte=   Defective dentate nucleus GABA receptors in essential tremor
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Defective dentate nucleus GABA receptors in essential tremor

Defective dentate nucleus GABA receptors in essential tremor

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri